Tag-Archive for ◊ Clinical trial ◊

Author:
• Tuesday, August 24th, 2010

Imagine that your boss tells you to lose weight. Why might this happen? There are two possible causes. For people suffering from excessive weight it can be physically difficult to do some work. There may also be issues over appearance. Not everyone fits into a uniform and looks good. Since many customers tend to judge the employer by the way the staff are presented, there’s pressure on employers to police the way you look. The second reason is pressure coming from the health insurance industry. It’s a statistical fact that the overweight are more likely to claim on health plans for longer term illnesses. This is forcing up premiums to employers but, to “help” those in financial difficulty, insurers are offering discounts if employers run wellness programs to incentivize their employees to lose weight. Allowing for many states allowing termination at-will, there are no real laws at a federal or state level to prevent discrimination on body weight. Unlike an injury leaving you partly paralyzed, the lawmakers say how much you weigh is a lifestyle decision and not a disability.

This problem is not restricted only to the US. For example in England people are fanatical about soccer. Benni McCarthy who should play for West Ham is overweight and has been told to lose about 12 pounds. The club will fine him about $60,000 out of his pay for every week he fails to lose 2 pounds. The club sees him through training, controls what he eats while at “work”, and then waves goodbye to him in the evening. If he’s not losing weight, it’s because of what he does out of sight. If we go over to Turkey, the state-run Turkish Airlines has suspended 28 flight attendants for being overweight. If these attendants, 15 of whom are men, do not get down to their target weights, they will be given work in the back office. In the meantime, they have no pay which will restrict the amount they can afford to eat and speed their weight loss.

So what would you do if your boss told you to lose weight? How much is your job worth to you? The Turkish flight attendants have been told to lose 10% of their body weight. They are finding it difficult to move easily up and down the aisles of the planes. By a strange coincidence, the clinical trials show participants losing an average of 10% of their body weight when using Acomplia. Would you diet and use an appetite suppressant to meet your boss’s expectations, or would you think this an interference with your private life and fight for your rights? Except, of course, your rights under the anti-discrimination laws are very limited. Even in a state which some protections against unreasonable termination, you may struggle to hold on to your job. So, it all comes back to a diet and Acomplia or giving up your paid work. Life can be really unfair.

Author:
• Wednesday, August 04th, 2010

The world’s first experiments using embryonic stem cells to treat humans have been given the go-ahead in America.

California-based bio-tech firm Geron will begin clinical trials on patients paralyzed by spinal cord injuries.

Scientists hope that injecting cells from discarded human embryos into the spines of volunteers will trigger regrowth of damaged nerve cells and eventually allow the patients to recover feeling and movement.

The Vatican condemned the controversial milestone as ‘ unacceptable’ and anti-abortion groups say they are planning protests across the country.

The study was cleared by President Obama a year ago, but was put on hold because some animals on which the company was testing the treatment developed cysts. Now Geron claims it has overcome the problem.

Dr Richard Fessler, a neurological surgeon at Northwestern University who will lead the research, said that if the treatment works on humans it would be ‘revolutionary’.

‘The therapy would provide a viable treatment option for thousands of patients who suffer severe spinal cord injuries each year,’ he said.

Geron has spent 15 years and more than £100million developing the treatment and hopes to begin the study within the next few months.

Adult stem cells, which typically produce a set variety of tissue types, have been tested on patients with limited success.

But researchers hope the use of highly versatile embryonic stem cells – which can turn into any cell in the body – will revolutionize medicine, from creating organs for transplants to helping to test drugs.

Stem cell trials are to be undertaken on patients with spinal cord injuries

The therapy also has the potential to help patients with Alzheimer’s disease and multiple sclerosis.

Until now, the ethical barrier of using discarded three- to five-day-old embryos has prevented any tests on humans.

The Bush administration, fearing a backlash from its many evangelical Christian supporters, kept embryonic stem cell research tightly shackled, but last year President Obama repealed the block.

The Roman Catholic Church remains fiercely opposed to the research. Vatican official Elio Dgreccia said: ‘Despite the efforts that are made to deny it, science continues to show us that the embryo is a human being in the making.’

One of Britain’s leading stem cell researchers, Dr Robin Lovell-Badge of the National Institute for Medical Research, said: ‘It is critical that the first steps to using human embryonic stem cell-derived cells for treatments are carried out with caution.

‘The last thing a field needs, especially one weighed down with so much ethical and political debate, is a disaster.

‘However, while it is right to proceed with care, at some point someone has to be brave. Many treatments that are today routine began with both the clinical teams and the patients taking a gamble, whether it was Christiaan Barnard and heart transplants or Edwards and Steptoe with IVF.’